18,027 research outputs found

    Hybridisations within the genus Schistosoma: implications for evolution, epidemiology and control

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    Interface refactoring in performance-constrained web services

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    This paper presents the development of REF-WS an approach to enable a Web Service provider to reliably evolve their service through the application of refactoring transformations. REF-WS is intended to aid service providers, particularly in a reliability and performance constrained domain as it permits upgraded ā€™non-backwards compatibleā€™ services to be deployed into a performance constrained network where existing consumers depend on an older version of the service interface. In order for this to be successful, the refactoring and message mediation needs to occur without affecting functional compatibility with the servicesā€™ consumers, and must operate within the performance overhead expected of the original service, introducing as little latency as possible. Furthermore, compared to a manually programmed solution, the presented approach enables the service developer to apply and parameterize refactorings with a level of confidence that they will not produce an invalid or ā€™corruptā€™ transformation of messages. This is achieved through the use of preconditions for the defined refactorings

    Should we be treating animal schistosomiasis in Africa? The need for a One Health economic evaluation of schistosomiasis control in people and their livestock

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    A One Health economic perspective allows informed decisions to be made regarding control priorities and/or implementation strategies for infectious diseases. Schistosomiasis is a major and highly resilient disease of both humans and livestock. The zoonotic component of transmission in sub-Saharan Africa appears to be more significant than previously assumed, and may thereby affect the recently revised WHO vision to eliminate schistosomiasis as a public health problem by 2025. Moreover, animal schistosomiasis is likely to be a significant cost to affected communities due to its direct and indirect impact on livelihoods. We argue here for a comprehensive evaluation of the economic burden of livestock and zoonotic schistosomiasis in sub-Saharan Africa in order to determine if extending treatment to include animal hosts in a One Health approach is economically, as well as epidemiologically, desirable

    Role of the exchange and correlation potential into calculating the x-ray absorption spectra of half-metallic alloys: the case of Mn and Cu K-edge XANES in Cu2_2MnM (M = Al, Sn, In) Heusler alloys

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    This work reports a theoretical study of the x-ray absorption near-edge structure spectra at both the Cu and the Mn K-edge in several Cu2_2MnM (M= Al, Sn and In) Heusler alloys. Our results show that {\it ab-initio} single-channel multiple-scattering calculations are able of reproducing the experimental spectra. Moreover, an extensive discussion is presented concerning the role of the final state potential needed to reproduce the experimental data of these half-metallic alloys. In particular, the effects of the cluster-size and of the exchange and correlation potential needed in reproducing all the experimental XANES features are discussed.Comment: 15 pages, 5 figure

    Ab-initio determined electronic and magnetic properties of half-metallic NiCrSi and NiMnSi Heusler alloys; the role of interfaces and defects

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    Using state-of-the-art first-principles calculations we study the properties of the ferromagnetic Heusler compounds NiYSi where Y stands for V, Cr or Mn. NiCrSi and NiMnSi contrary to NiVSi are half-metallic at their equilibrium lattice constant exhibiting integer values of the total spin magnetic moment and thus we concentrate on these two alloys. The minority-spin gap has the same characteristics as for the well-known NiMnSb alloy being around āˆ¼\sim1 eV. Upon tetragonalization the gap is present in the density of states even for expansion or contraction of the out-of-plane lattice parameter by 5%. The Cr-Cr and Mn-Mn interactions make ferromagnetism extremely stable and the Curie temperature exceeds 1000 K for NiMnSi. Surface and interfaces with GaP, ZnS and Si semiconductors are not half-metallic but in the case of NiCrSi the Ni-based contacts present spin-polarization at the Fermi level over 90%. Finally, we show that there are two cases of defects and atomic-swaps. The first-ones which involve the Cr(Mn) and Si atoms induce states at the edges of the gap which persists for a moderate-concentration of defects. Defects involving Ni atoms induce states localized within the gap completely destroying the half-metallicity. Based on single-impurity calculations we associate these states to the symmetry of the crystal

    3d-electron induced magnetic phase transition in half-metallic semi-Heusler alloys

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    We study the effect of the non-magnetic 3\textit{d} atoms on the magnetic properties of the half-metallic (HM) semi-Heusler alloys Co1āˆ’x_{1-x}Cux_{x}MnSb and Ni1āˆ’x_{1-x}Cux_{x}MnSb (0ā‰¤xā‰¤10 \leq x \leq 1) using first-principles calculations. We determine the magnetic phase diagram of both systems at zero temperature and obtain a phase transition from a ferromagnetic to an antiferromagnetic state. For low Cu concentrations the ferromagnetic RKKY-like exchange mechanism is dominating, while the antiferromagnetic superexchange coupling becomes important for larger Cu content leading to the observed magnetic phase transition. A strong dependence of the magnetism in both systems on the position of the Fermi level within the HM gap is obtained. Obtained results are in good agreement with the available experimental data

    Quasar-galaxy associations

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    There is controversy about the measurement of statistical associations between bright quasars and faint, presumably foreground galaxies. We look at the distribution of galaxies around an unbiased sample of 63 bright, moderate redshift quasars using a new statistic based on the separation of the quasar and its nearest neighbour galaxy. We find a significant excess of close neighbours at separations less than about 10 arcsec which we attribute to the magnification by gravitational lensing of quasars which would otherwise be too faint to be included in our sample. About one quarter to one third of the quasars are so affected although the allowed error in this fraction is large.Comment: uuencoded Postscript file (including figures and tables), SUSSEX-AST 94/8-

    Fine-grained timing using genetic programming

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    In previous work, we have demonstrated that it is possible to use Genetic Programming to minimise the resource consumption of software, such as its power consumption or execution time. In this paper, we investigate the extent to which Genetic Programming can be used to gain fine-grained control over software timing. We introduce the ideas behind our work, and carry out experimentation to find that Genetic Programming is indeed able to produce software with unusual and desirable timing properties, where it is not obvious how a manual approach could replicate such results. In general, we discover that Genetic Programming is most effective in controlling statistical properties of software rather than precise control over its timing for individual inputs. This control may find useful application in cryptography and embedded systems

    Establishing the potential for using routine data on Incapacity Benefit to assess the local impact of policy initiatives

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    <i>Background</i>: Incapacity Benefit (IB) is the key contributory benefit for people who are incapable of work because of illness or disability. <i>Methods</i>: The aims were to establish the utility of routinely collected data for local evaluation and to provide a descriptive epidemiology of the IB population in Glasgow and Scotland for the period 2000ā€“05 using data supplied by the Department for Work and Pensions. <i>Results</i>: Glasgow's IB population is large in absolute and relative terms but is now falling, mainly due to a decrease in on flow. Claimants, tend to be older, have a poor work history and suffer from mental health problems. The rate of decline has been greater in Glasgow than Scotland, although the rate of on flow is still higher. <i>Conclusions</i>: Department for Work and Pensions (DWP) data can be used locally to provide important insights into the dynamics of the IB population. However, to be truly useful, more work needs to be undertaken to combine the DWP data with other information
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